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In the current study, the pattern of OLIG2 expression in a spectrum of 90 non-oligodendroglial pediatric gliomas varied from very low levels in the ependymomas (cellular and tanycytic) to high levels in pilocytic astrocytoma, and in the diffuse-type astrocytic tumors (WHO grades II–IV).

The pediatric gliomas have genomic profiles that are different from the corresponding adult tumors and accordingly, the expression of OLIG2 in non-oligodendroglial pediatric gliomas is not well documented within specific tumor types. In addition, it is functionally required for the formation of high-grade astrocytomas in a genetically relevant murine model. The bHLH transcription factor, OLIG2, is universally expressed in adult human gliomas and, as a major factor in the development of oligodendrocytes, is expressed at the highest levels in low-grade oligodendroglial tumors.

Self-self correlations are on diagonal and have a correlation coefficient of 1.0. (D) Heat map of array-array Spearman rank correlation coefficients. Elements with a signal less than 0.8 of the mean are negative controls. Elements with intensity greater than 1.2 times the mean of the group are considered positive controls. For each array, the intensities for all border elements are collected. (C) Box plot of positive and negative element intensities.

(B) Kernal density estimates of the box plot intensities. Key: 1 = accession number GSM541060.cel 2 = GSM541061.cel’ 3 = GSM541063.cel 4 = GSM132714.CEL, 5 = GSM132715.CEL, 6 = GSM132716.CEL Arrays 1-3 are the ependymoma arrays performed by Johnson et al arrays 4-6 are the pilocytic astrocytoma arrays performed by Sharma et al (A) Box plot of average pm probe intensities across the 6 arrays tested. 1: Quality control analysis of expression data in pilocytic astrocytoma and ependymoma microarray data.

Account hacker v3.9.9 activation key .txt